Emerging Non-Canonical Functions and Regulation of p53

Int J Mol Sci. 2018 Mar 28;19(4):1015. doi: 10.3390/ijms19041015.

Abstract

The tumor suppressor p53 induces cell cycle arrest and/or apoptosis by transactivating numerous downstream target genes and also translocating to the mitochondrial outer membrane.

Publication types

  • Editorial

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Apoptosis / genetics*
  • Cell Cycle Checkpoints / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Mutation, Missense*
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Tumor Suppressor Protein p53* / genetics
  • Tumor Suppressor Protein p53* / metabolism

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53