Abstract
Background:
A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.
Results:
In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.
Conclusion:
The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.
Keywords:
1,3,4-thiadiazoles; analgesic and anti-ulcer agents; anti-inflammatory; fused imidazoles; heterocyclic amines; microwave irradiation..
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MeSH terms
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Analgesics / chemical synthesis
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Analgesics / chemistry*
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Analgesics / pharmacology
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Anti-Ulcer Agents / chemical synthesis
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Anti-Ulcer Agents / chemistry*
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Anti-Ulcer Agents / pharmacology
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Anti-Ulcer Agents / therapeutic use
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Chemistry Techniques, Synthetic / methods
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Cyclooxygenase 2 / metabolism
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Edema / drug therapy
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Edema / metabolism
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Imidazoles / therapeutic use
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Microwaves
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Molecular Docking Simulation
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Rats
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Stomach Ulcer / drug therapy
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Stomach Ulcer / metabolism
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Thiadiazoles / chemical synthesis
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Thiadiazoles / chemistry*
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Thiadiazoles / pharmacology
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Thiadiazoles / therapeutic use
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Anti-Ulcer Agents
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Imidazoles
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Thiadiazoles
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Cyclooxygenase 2