A supramolecular self-assembly strategy for upconversion nanoparticle bioconjugation

Yulong Sun; Wenjing Zhang; Baoming Wang; Xiaoxue Xu; Joshua Chou; Olga Shimoni; Alison T Ung; Dayong Jin

doi:10.1039/c8cc00708j

A supramolecular self-assembly strategy for upconversion nanoparticle bioconjugation

Chem Commun (Camb). 2018 Apr 12;54(31):3851-3854. doi: 10.1039/c8cc00708j.

Authors

Yulong Sun¹, Wenjing Zhang², Baoming Wang³, Xiaoxue Xu³, Joshua Chou⁴, Olga Shimoni¹, Alison T Ung⁵, Dayong Jin¹

Affiliations

¹ Institute of Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Ultimo, Sydney, NSW 2007, Australia and ARC Research Hub of Integrated Device for End-user Analysis at Low-level (IDEAL), Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia and School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.
² Institute of Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Ultimo, Sydney, NSW 2007, Australia and School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia and Institute of Advanced Materials for Nano-Bio Application, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, 310012, P. R. China.
³ Institute of Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Ultimo, Sydney, NSW 2007, Australia and School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.
⁴ School of Life Science, Advanced Tissue Regeneration and Drug Delivery Group, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia. dayong.jin@uts.edu.au olga.shimoni@uts.edu.au.
⁵ School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.

PMID: 29594291
DOI: 10.1039/c8cc00708j

Abstract

An efficient surface modification for upconversion nanoparticles (UCNPs) is reported via supramolecular host-guest self-assembly. Cucurbit[7]uril (CB) can provide a hydrophilic surface and cavities for most biomolecules. High biological efficiency, activity and versatility of the approach enable UCNPs to be significantly applied in bio-imaging, early disease detection, and bio-sensing.

MeSH terms

Adamantane / analogs & derivatives
Adamantane / chemistry
Bridged-Ring Compounds / chemistry*
Bridged-Ring Compounds / toxicity
Cadherins / chemistry
Europium / chemistry
Fluorides / chemistry
HeLa Cells
Humans
Hydrophobic and Hydrophilic Interactions
Imidazoles / chemistry*
Imidazoles / toxicity
Immunoglobulin G / chemistry
Ligands
Metal Nanoparticles / chemistry*
Metal Nanoparticles / toxicity
Particle Size
Ytterbium / chemistry
Yttrium / chemistry

Substances

Bridged-Ring Compounds
Cadherins
Imidazoles
Immunoglobulin G
Ligands
cucurbit(7)uril
sodium yttriumtetrafluoride
Europium
Yttrium
adamantanecarboxylic acid
Ytterbium
Adamantane
Fluorides