Genetic Relationships among Multidrug-Resistant Salmonella enterica Serovar Typhimurium Strains from Humans and Animals

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00213-18. doi: 10.1128/AAC.00213-18. Print 2018 May.

Abstract

We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.

Keywords: Salmonella; Salmonella enterica serovar Typhimurium; antimicrobial resistance; mechanisms of resistance; plasmids; whole-genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology
  • Chickens
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Humans
  • Microbial Sensitivity Tests
  • Multigene Family / genetics
  • Plasmids / genetics*
  • Salmonella Infections, Animal
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / isolation & purification
  • Swine
  • Taiwan
  • Whole Genome Sequencing

Substances

  • Anti-Bacterial Agents
  • Azithromycin