Clinical and Microbiological Characteristics of Candida guilliermondii and Candida fermentati

Tatsuro Hirayama; Taiga Miyazaki; Yuka Yamagishi; Hiroshige Mikamo; Takashi Ueda; Kazuhiko Nakajima; Yoshio Takesue; Yoshitsugu Higashi; Yoshihiro Yamamoto; Muneyoshi Kimura; Hideki Araoka; Shuichi Taniguchi; Yuichi Fukuda; Yumi Matsuo; Akiko Furutani; Kohei Yamashita; Takahiro Takazono; Tomomi Saijo; Shintaro Shimamura; Kazuko Yamamoto; Yoshifumi Imamura; Koichi Izumikawa; Katsunori Yanagihara; Shigeru Kohno; Hiroshi Mukae

doi:10.1128/AAC.02528-17

Clinical and Microbiological Characteristics of Candida guilliermondii and Candida fermentati

Antimicrob Agents Chemother. 2018 May 25;62(6):e02528-17. doi: 10.1128/AAC.02528-17. Print 2018 Jun.

Authors

Tatsuro Hirayama^{1

2}, Taiga Miyazaki^{3

4}, Yuka Yamagishi⁵, Hiroshige Mikamo⁵, Takashi Ueda⁶, Kazuhiko Nakajima⁶, Yoshio Takesue⁶, Yoshitsugu Higashi⁷, Yoshihiro Yamamoto⁷, Muneyoshi Kimura⁸, Hideki Araoka⁸, Shuichi Taniguchi⁹, Yuichi Fukuda¹⁰, Yumi Matsuo¹¹, Akiko Furutani¹², Kohei Yamashita¹, Takahiro Takazono^{2

4}, Tomomi Saijo², Shintaro Shimamura², Kazuko Yamamoto², Yoshifumi Imamura², Koichi Izumikawa⁴, Katsunori Yanagihara¹³, Shigeru Kohno², Hiroshi Mukae^{1

2}

Affiliations

¹ Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
² Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
³ Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan taiga-m@nagasaki-u.ac.jp.
⁴ Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
⁵ Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute, Japan.
⁶ Department of Infection Control and Prevention, Hyogo College of Medicine, Nishinomiya, Japan.
⁷ Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.
⁸ Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan.
⁹ Department of Hematology, Toranomon Hospital, Tokyo, Japan.
¹⁰ Department of Respiratory Medicine, Sasebo City General Hospital, Sasebo, Japan.
¹¹ Department of Laboratory Medicine, Sasebo City General Hospital, Sasebo, Japan.
¹² Department of Laboratory Medicine, Sasebo Kyosai Hospital, Sasebo, Japan.
¹³ Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Abstract

A total of 46 clinical isolates of Candida guilliermondii and Candida famata were reidentified genetically, resulting in 27 C. guilliermondii and 12 Candida fermentati strains. The majority of C. guilliermondii strains, but not C. fermentati strains, were isolated from blood cultures. C. fermentati was more sensitive to antifungals, hydrogen peroxide, and killing by murine macrophages than was C. guilliermondii The C. guilliermondii isolates were echinocandin susceptible in vitro but resistant to micafungin in a murine model of invasive candidiasis.

Keywords: Candida fermentati; Candida guilliermondii; antifungal resistance; echinocandin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Animals
Antifungal Agents / pharmacology*
Candida / drug effects*
Candidiasis / drug therapy
Candidiasis / microbiology
Echinocandins / pharmacology*
Female
Humans
Hydrogen Peroxide / pharmacology
Male
Micafungin / pharmacology
Mice
Microbial Sensitivity Tests
Middle Aged

Substances

Antifungal Agents
Echinocandins
Hydrogen Peroxide
Micafungin

Supplementary concepts

Systemic candidiasis