Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare

Akin Nihat; Simon Mead

doi:10.1186/s13073-018-0536-3

Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare

Genome Med. 2018 Mar 26;10(1):22. doi: 10.1186/s13073-018-0536-3.

Authors

Akin Nihat^{1

2}, Simon Mead^{3

4}

Affiliations

¹ National Prion Clinic, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.
² Medical Research Council Prion Unit at University College London (UCL), Institute of Prion Diseases, London, W1W 7FF, UK.
³ National Prion Clinic, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK. s.mead@prion.ucl.ac.uk.
⁴ Medical Research Council Prion Unit at University College London (UCL), Institute of Prion Diseases, London, W1W 7FF, UK. s.mead@prion.ucl.ac.uk.

Abstract

Evidence has recently been reported of prion seeding activity in skin tissue from patients with sporadic Creutzfeldt-Jakob disease (sCJD). This is relevant information for infection control measures during surgery. The work uses very sensitive prion assays now available for medical research, and may soon be adapted to related neurodegenerative disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Creutzfeldt-Jakob Syndrome / diagnosis*
Creutzfeldt-Jakob Syndrome / prevention & control
Delivery of Health Care*
Humans
Prions / metabolism*
Skin / metabolism*
Skin / pathology

Substances

Prions

Abstract

Publication types

MeSH terms

Substances

Grants and funding