As a follow-up to the overview of reviews conducted for Research Questions 1a and 1b in the main health technology assessment (HTA) protocol, and to address gaps within the published systematic review (SR) literature, an SR of relevant published primary studies on the clinical effectiveness, comparative clinical effectiveness, and safety of interventions for the treatment of obstructive sleep apnea (OSA) in adults will be conducted. Specifically, this SR will focus on addressing Research Questions 1a and 1b, in relation to certain combinations of interventions, comparators, and outcomes that are missing in the overview of reviews, as listed in Table 1.
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