Blockade of Granzyme B Remarkably Improves Mucocutaneous Diseases with Keratinocyte Death in Interface Dermatitis

J Invest Dermatol. 2018 Sep;138(9):2079-2083. doi: 10.1016/j.jid.2018.03.1507. Epub 2018 Mar 22.

Authors

Akimasa Saito¹, Naoko Okiyama², Noriko Kubota¹, Yoshiyuki Nakamura¹, Yasuhiro Fujisawa¹, Rei Watanabe¹, Yosuke Ishitsuka¹, R Chris Bleackley³, Manabu Fujimoto¹

Affiliations

¹ Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
² Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: naoko.okiyama@md.tsukuba.ac.jp.
³ Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

PMID: 29577918
DOI: 10.1016/j.jid.2018.03.1507

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Biological Factors / therapeutic use*
Dermatitis / drug therapy*
Dermatitis / metabolism
Dermatitis / pathology
Granzymes / antagonists & inhibitors*
Keratinocytes / drug effects
Keratinocytes / metabolism
Keratinocytes / pathology*
Mice

Substances

Biological Factors
Granzymes