Biotin-functionalized targeted polydiacetylene micelles

Chem Commun (Camb). 2018 Apr 5;54(29):3613-3616. doi: 10.1039/c8cc00553b.

Abstract

Polydiacetylene micelles were functionalized with controlled amounts of biotin using bioorthogonal click chemistry. The biotinylated micelles were evaluated in the selective targeting of the MCF-7 cancerous cell line and were shown to be readily internalized. The efficiency of the cellular uptake was correlated to the density of grafted biotin.

MeSH terms

  • Biotin / analogs & derivatives*
  • Biotin / metabolism
  • Biotinylation
  • Click Chemistry
  • Humans
  • MCF-7 Cells
  • Micelles*
  • Polyacetylene Polymer
  • Polymerization
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Polymers / metabolism
  • Polyynes / chemical synthesis
  • Polyynes / chemistry*
  • Polyynes / metabolism
  • Receptors, Growth Factor / metabolism

Substances

  • Micelles
  • Polyacetylene Polymer
  • Polymers
  • Receptors, Growth Factor
  • biotin receptor
  • Polyynes
  • polydiacetylene
  • Biotin