Abstract
Polydiacetylene micelles were functionalized with controlled amounts of biotin using bioorthogonal click chemistry. The biotinylated micelles were evaluated in the selective targeting of the MCF-7 cancerous cell line and were shown to be readily internalized. The efficiency of the cellular uptake was correlated to the density of grafted biotin.
MeSH terms
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Biotin / analogs & derivatives*
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Biotin / metabolism
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Biotinylation
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Click Chemistry
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Humans
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MCF-7 Cells
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Micelles*
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Polyacetylene Polymer
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Polymerization
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Polymers / chemical synthesis
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Polymers / chemistry*
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Polymers / metabolism
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Polyynes / chemical synthesis
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Polyynes / chemistry*
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Polyynes / metabolism
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Receptors, Growth Factor / metabolism
Substances
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Micelles
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Polyacetylene Polymer
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Polymers
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Receptors, Growth Factor
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biotin receptor
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Polyynes
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polydiacetylene
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Biotin