AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans

Jiajun Fu; Haining Zhang; Wenming Huang; Xinyu Zhu; Yi Sheng; Eli Song; Tao Xu

doi:10.1007/s41048-018-0046-2

AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans

Biophys Rep. 2018;4(1):17-24. doi: 10.1007/s41048-018-0046-2. Epub 2018 Mar 5.

Authors

Jiajun Fu^{1

2}, Haining Zhang^{1

3}, Wenming Huang^{1

3}, Xinyu Zhu^{1

3}, Yi Sheng^{1

3}, Eli Song¹, Tao Xu^{1

2

3}

Affiliations

¹ 1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
² 2College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049 China.
³ 3Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 China.

Abstract

Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.

Keywords: AIM interneurons; C. elegans; Peripheral feeding regulation; TYRA-2 receptor; Tyramine.