Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma (HCC). The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC. This manuscript explores the most recent studies to indicate its unique anti-tumor immune response. The possible immune mechanism, termed as nano-pulse stimulation, was also analyzed.
Keywords: Hepatocellular carcinoma (HCC); Locoregional therapy; Nano-pulse stimulation (NPS); Nanosecond pulsed electric field (nsPEF).