Characterization of a novel allele, HLA-C*02:135N, by full-length gene sequencing in a bone marrow donor

HLA. 2018 Jun;91(6):538-539. doi: 10.1111/tan.13260.

Abstract

A frameshift because of a two-nucleotide deletion results in an HLA-C null allele, HLA-C*02:135N.

Keywords: Illumina Miseq; Pacific Biosciences; Sanger sequencing; frameshift mutation; next-generation sequencing; novel HLA-C null allele.

MeSH terms

  • Alleles
  • Bone Marrow / physiology*
  • Bone Marrow Transplantation
  • Canada
  • Genotype*
  • HLA-C Antigens / genetics*
  • Histocompatibility Testing
  • Humans
  • Loss of Function Mutation / genetics*
  • Sequence Analysis, DNA
  • Tissue Donors
  • White People*
  • World Health Organization

Substances

  • HLA-C Antigens
  • HLA-C*02 antigen