Ruthenium-Catalyzed Selective C-C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst

Ying-Qi Xia; Chao Li; Man Liu; Lin Dong

doi:10.1002/chem.201706080

Ruthenium-Catalyzed Selective C-C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst

Chemistry. 2018 Apr 11;24(21):5474-5478. doi: 10.1002/chem.201706080. Epub 2018 Mar 25.

Authors

Ying-Qi Xia¹, Chao Li¹, Man Liu¹, Lin Dong¹

Affiliation

¹ Key laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, 610041, Chengdu, China.

PMID: 29575207
DOI: 10.1002/chem.201706080

Abstract

Versatile reactive activities of allyl alcohols with free indoles in C-H functionalization reactions were investigated. Direct alkylation or cascade cyclization reactions could be selectively controlled based on the catalyst system: Ru(PPh₃ )₃ Cl₂ provided C3-substituted β-ketone indoles whereas [Ru(p-cymene)Cl₂ ]₂ yielded cyclized indoles.

Keywords: allylic alcohols; free indoles; ruthenium; selective C−C coupling; β-ketone indoles.