Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)

Jirong Jia; Yazhou Zhang; Xi Yuan; Jingkai Qin; Guokun Yang; Xiaozheng Yu; Bin Wang; Caiyun Sun; Wensheng Li

doi:10.1016/j.bbrc.2018.03.149

Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)

Biochem Biophys Res Commun. 2018 May 5;499(2):285-290. doi: 10.1016/j.bbrc.2018.03.149. Epub 2018 Mar 24.

Authors

Jirong Jia¹, Yazhou Zhang¹, Xi Yuan¹, Jingkai Qin¹, Guokun Yang¹, Xiaozheng Yu¹, Bin Wang¹, Caiyun Sun¹, Wensheng Li²

Affiliations

¹ State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, Guangdong Provincial Engineering Technology Research Center of Healthy Breeding in Important Economic Fish, South China Sea Bio-Resource Exploitation and Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
² State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, Guangdong Provincial Engineering Technology Research Center of Healthy Breeding in Important Economic Fish, South China Sea Bio-Resource Exploitation and Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China. Electronic address: lsslws@mail.sysu.edu.cn.

PMID: 29574160
DOI: 10.1016/j.bbrc.2018.03.149

Abstract

Compensatory growth (CG) is defined as a phase of accelerated growth when the disadvantageous environment is improved, accompanied by metabolic adjustment. Here, we report that hepatic oxidative phosphorylation (OXPHOS) activity was enhanced during compensatory growth in zebrafish. Mitochondrial metabolism enabled the generation of reactive oxygen species (ROS), which activated the nrf2 (nuclear factor-erythroid 2-related factor 2) signaling pathway, as well as the mTOR signaling pathway. Tempol (a superoxide dismutase mimetic) treatment blocked ROS signaling in the liver as well as CG in zebrafish. These results demonstrated that mitochondrial ROS signaling are essential for the occurrence of compensatory growth in zebrafish.

Keywords: Compensatory growth; Liver; Reactive oxygen species; Zebrafish; mTOR; nrf2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclic N-Oxides / pharmacology
Feeding Behavior / drug effects
Female
Intestinal Mucosa / metabolism
Intestines / drug effects
Liver / drug effects
Liver / physiology*
Mitochondria, Liver / drug effects
Mitochondria, Liver / metabolism
Muscle Fibers, Skeletal / drug effects
Muscle Fibers, Skeletal / metabolism
Oxidative Phosphorylation / drug effects
Reactive Oxygen Species / metabolism*
Signal Transduction / drug effects
Spin Labels
Zebrafish / growth & development*
Zebrafish / metabolism*

Substances

Cyclic N-Oxides
Reactive Oxygen Species
Spin Labels
tempol