Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?

Mustafa M A Elsayed; Ahmed O Shalash

doi:10.1016/j.jconrel.2018.03.020

Modeling the performance of carrier-based dry powder inhalation formulations: Where are we, and how to get there?

J Control Release. 2018 Jun 10:279:251-261. doi: 10.1016/j.jconrel.2018.03.020. Epub 2018 Mar 21.

Authors

Mustafa M A Elsayed¹, Ahmed O Shalash²

Affiliations

¹ College of Pharmacy, University of Hail, Hail, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. Electronic address: mustafa.elsayed@alexpharmres.com.
² Medizen Pharmaceutical Industries, Alexandria, Egypt.

PMID: 29574042
DOI: 10.1016/j.jconrel.2018.03.020

Abstract

Development of carrier-based dry powder inhalation formulations follows till date empirical approaches. This is mainly underlain by numerousness of interplaying determinants of performance and complexity of involved interactions. Mathematical modeling helps elucidate such interactions and aids rational development of formulations. This article provides a critical overview of attempts made to model the performance of carrier-based dry powder inhalation formulations. The complex dependence of the performance on formulation properties is comprehensively discussed. A potential microstructure-based model is ultimately introduced.

Keywords: Dry powder inhalation; Excipient/carrier; Mathematical modeling; Microstructure; Physicochemical determinants of performance.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Inhalation
Chemistry, Pharmaceutical / methods*
Drug Carriers / chemistry*
Drug Compounding / methods
Dry Powder Inhalers
Humans
Models, Theoretical*

Substances

Drug Carriers