Increased building block access through collaboration

Drug Discov Today. 2018 Aug;23(8):1458-1462. doi: 10.1016/j.drudis.2018.03.001. Epub 2018 Mar 20.

Authors

Christopher J Helal¹, Alessandra Bartolozzi², Steven D Goble³, Neelakanda S Mani⁴, Angel Guzman-Perez⁵, Ajay K Ohri⁶, Zhi-Cai Shi³, Chakrapani Subramanyam⁷

Affiliations

¹ Pfizer, Eastern Point Rd, Groton, CT 06340, USA. Electronic address: chris.j.helal@pfizer.com.
² Boehringer-Ingelheim, 900 Ridgebury Road, Ridgefield, CT 06877, USA. Electronic address: abartolozzi@bartolozzi-consulting.com.
³ Merck&Co., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
⁴ Janssen Pharmaceuticals, 3210 Merryfield Row, San Diego, CA 92121, USA.
⁵ Amgen, 360 Binney Street, Cambridge, MA 02142, USA.
⁶ Navin Fluorine International Limited, 2nd Floor, Sunteck Centre, 37/40, Subhash Road, Vile Parle (E), Mumbai 400057, India.
⁷ Pfizer, Eastern Point Rd, Groton, CT 06340, USA.

PMID: 29571837
DOI: 10.1016/j.drudis.2018.03.001

No abstract available

Publication types

Review

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
3',5'-Cyclic-AMP Phosphodiesterases / chemistry
3',5'-Cyclic-AMP Phosphodiesterases / metabolism
Animals
Cooperative Behavior*
Drug Industry / organization & administration*
Humans
Interdisciplinary Communication*
Phosphodiesterase Inhibitors / chemical synthesis*
Phosphodiesterase Inhibitors / pharmacology
Protein Conformation
Pyrimidinones / chemical synthesis*
Pyrimidinones / pharmacology
Structure-Activity Relationship
Triazoles / chemical synthesis*
Triazoles / pharmacology

Substances

Phosphodiesterase Inhibitors
Pyrimidinones
Triazoles
3',5'-Cyclic-AMP Phosphodiesterases
PDE9A protein, human