Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy

Xijian Liu; Yeying Wang; Qiyang Yu; Guoying Deng; Qian Wang; Xinhui Ma; Qiugen Wang; Jie Lu

doi:10.1016/j.colsurfb.2018.03.018

Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy

Colloids Surf B Biointerfaces. 2018 Jun 1:166:161-169. doi: 10.1016/j.colsurfb.2018.03.018. Epub 2018 Mar 15.

Authors

Xijian Liu¹, Yeying Wang², Qiyang Yu², Guoying Deng³, Qian Wang³, Xinhui Ma⁴, Qiugen Wang³, Jie Lu⁵

Affiliations

¹ College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China. Electronic address: liuxijian@sues.edu.cn.
² College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
³ Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, NO. 650 Xin Songjiang Road, Shanghai, 201620, China.
⁴ Shanghai Huaxi Chemical Industry Science & Technology Co.,Ltd. No.555,Huangqiao Road, Shanghai, 201315, China.
⁵ College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China. Electronic address: dr.lujie@foxmail.com.

PMID: 29571159
DOI: 10.1016/j.colsurfb.2018.03.018

Abstract

A multifunctional selenium nanocomposite (selenium@silica core-shell nanoshperes for loading indocyanine green(ICG)/Doxorubicin(DOX)) was fabricated to reach visible and efficient cancer treatment. The Se@SiO₂-ICG nanocomposites could be used not only as excellent photothermal agents but also as carriers for DOX delivery. In addition, the Se@SiO₂-ICG/DOX nanocomposites exhibited excellent fluorescence imaging and infrared imaging performance. Tumor could be effectively inhibited by Se@SiO₂-ICG/DOX due to the triple treatment of photothermal effect and chemotherapy of selenium and DOX. Thus, the Se@SiO₂-ICG/DOX nanocomposites have a great potential in imaging guiding synergistic treatment of cancer.

Keywords: Drug delivery; Fluorescence imaging; Photothermal therapy; Selenium nanocomposites; Synergistic treatment.

MeSH terms

Doxorubicin / chemistry*
Drug Carriers / chemistry
Humans
Nanocomposites / chemistry*
Phototherapy
Selenium / chemistry*

Substances

Drug Carriers
Doxorubicin
Selenium