Guideline on the management of occupational and non-occupational exposure to the human immunodeficiency virus and recommendations for post-exposure prophylaxis: 2015 Update

Michelle Moorhouse; Linda G Bekker; Vivian Black; Francesca Conradie; Beth Harley; Pauline Howell; Gary Maartens; Tari Papavarnavas; Kevin Rebe; Gillian Sorour; Francois Venter; Carole L Wallis

doi:10.4102/sajhivmed.v16i1.399

Guideline on the management of occupational and non-occupational exposure to the human immunodeficiency virus and recommendations for post-exposure prophylaxis: 2015 Update

South Afr J HIV Med. 2015 Nov 10;16(1):399. doi: 10.4102/sajhivmed.v16i1.399. eCollection 2015.

Authors

Michelle Moorhouse¹, Linda G Bekker², Vivian Black¹, Francesca Conradie³, Beth Harley⁴, Pauline Howell⁵, Gary Maartens⁶, Tari Papavarnavas⁷, Kevin Rebe⁸, Gillian Sorour^{9

10}, Francois Venter¹, Carole L Wallis^{11

12}

Affiliations

¹ Wits Reproductive Health and HIV Institute, Johannesburg, South Africa.
² The Desmond Tutu HIV Centre, University of Cape Town, South Africa.
³ Right to Care and Clinical HIV Research Unit, University of Witwatersrand, South Africa.
⁴ City Health, City of Cape Town, South Africa.
⁵ Wits Health Consortium, University of Witwatersrand, South Africa.
⁶ Department of Medicine, University of Cape Town, South Africa.
⁷ Helen Joseph Hospital, Right to Care, South Africa.
⁸ Anova Health Institute, Johannesburg, South Africa.
⁹ Gauteng Department of Health, Gauteng, South Africa.
¹⁰ President's Emergency Plan for AIDS Relief, Wits Reproductive Health & HIV Institute, South Africa.
¹¹ BARC, Johannesburg, South Africa.
¹² Lancet Laboratories, Johannesburg, South Africa.

Abstract

This guideline is an update of the post-exposure prophylaxis (PEP) guideline published by the Southern African HIV Clinicians Society in 2008. It updates the recommendations on the use of antiretroviral medications to prevent individuals who have been exposed to a potential HIV source, via either occupational or non-occupational exposure, from becoming infected with HIV. No distinction is made between occupational or non-occupational exposure, and the guideline promotes the provision of PEP with three antiretroviral drugs if the exposure confers a significant transmission risk. The present guideline aligns with the principles of the World Health Organization PEP guidelines (2014), promoting simplification and adherence support to individuals receiving PEP.