Sleep, Anesthesia, and Plasticity

Igor Timofeev; Sylvain Chauvette

doi:10.1016/j.neuron.2018.03.013

Sleep, Anesthesia, and Plasticity

Neuron. 2018 Mar 21;97(6):1200-1202. doi: 10.1016/j.neuron.2018.03.013.

Authors

Igor Timofeev¹, Sylvain Chauvette²

Affiliations

¹ Department of Psychiatry and Neuroscience, Université Laval, Québec G1V 0A6, Canada; CERVO Brain Research Center, Université Laval, Québec G1J 2G3, Canada. Electronic address: Igor.Timofeev@fmed.ulaval.ca.
² CERVO Brain Research Center, Université Laval, Québec G1J 2G3, Canada.

PMID: 29566787
DOI: 10.1016/j.neuron.2018.03.013

Abstract

Two theories continuously clash: does sleep downscale or potentiate synapses? A study in Neuron by González-Rueda et al. (2018) demonstrates overall synaptic depression during anesthesia-induced slow-wave activity. Because anesthesia is typically associated with amnesia, the question of whether slow-wave sleep potentiates or depresses cortical synapses remains open.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Anesthesia*
Neuronal Plasticity*
Neurons
Sleep
Synapses