Measuring Retinal Function in the Mouse

Methods Mol Biol. 2018:1753:27-40. doi: 10.1007/978-1-4939-7720-8_2.

Abstract

Electroretinography is a crucial assay for studying the function and the functional integrity of the retina. The mouse is an important animal model for studying the retinal neurons and circuitries. In addition, it is often used as animal model for human retinal disorders. Therefore, a good understanding of the procedures in animal handling, of the methods for data analysis and of the requirements for stimulators and for the data acquisition equipment is of importance. Here, the currently most common methods and materials for in vivo electroretinography in the mouse are discussed.

Keywords: A-wave; Analysis; Anesthesia; B-wave; ERG; Electroretinogram; Equipment; Oscillatory potentials; Stimulators.

Publication types

  • Review

MeSH terms

  • Animals
  • Data Analysis
  • Disease Models, Animal*
  • Electroretinography / instrumentation
  • Electroretinography / methods*
  • Humans
  • Mice
  • Photic Stimulation / instrumentation
  • Photic Stimulation / methods*
  • Retina / physiopathology*
  • Retinal Diseases / diagnostic imaging*
  • Retinal Diseases / physiopathology