A Developmental Switch in Microglial HDAC Function

Hansruedi Mathys; Jay Penney; Li-Huei Tsai

doi:10.1016/j.immuni.2018.03.010

A Developmental Switch in Microglial HDAC Function

Immunity. 2018 Mar 20;48(3):476-478. doi: 10.1016/j.immuni.2018.03.010.

Authors

Hansruedi Mathys¹, Jay Penney¹, Li-Huei Tsai²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: lhtsai@mit.edu.

PMID: 29562197
DOI: 10.1016/j.immuni.2018.03.010

Abstract

The epigenetic mechanisms controlling microglia functions are largely unknown. In this issue of Immunity, Datta et al. (2018) uncover surprising and distinct effects of deleting the epigenetic regulators HDAC1 and HDAC2 during microglial development versus during the course of neurodegeneration.

Publication types

Comment

MeSH terms

Epigenesis, Genetic
Histone Deacetylase 2 / genetics*
Microglia*

Substances

Histone Deacetylase 2