Fucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer

Bian Jang; Madhappan Santha Moorthy; Panchanathan Manivasagan; Li Xu; Kyeongeun Song; Kang Dae Lee; Minseok Kwak; Junghwan Oh; Jun-O Jin

doi:10.18632/oncotarget.23898

Fucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer

Oncotarget. 2018 Jan 3;9(16):12649-12661. doi: 10.18632/oncotarget.23898. eCollection 2018 Feb 27.

Authors

Bian Jang^{1

2

3

4}, Madhappan Santha Moorthy², Panchanathan Manivasagan², Li Xu¹, Kyeongeun Song^{1

2}, Kang Dae Lee⁵, Minseok Kwak^{2

6}, Junghwan Oh^{2

3

4}, Jun-O Jin¹

Affiliations

¹ Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Jinshan District, Shanghai, China.
² Marine-Integrated Bionics Research Center, Pukyong National University, Busan, South Korea.
³ Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Busan, South Korea.
⁴ Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Busan, South Korea.
⁵ Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
⁶ Department of Chemistry, Pukyong National University, Busan, South Korea.

Abstract

In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells. Fucoidan-coated copper sulfide nanoparticles (F-CuS) act not only as a nanocarrier to enhance the intracellular delivery of fucoidan but also as a photothermal agent to effectively ablate different cancer cells (e.g., HeLa, A549, and K562), both in vitro and in vivo, with the induction of apoptosis under 808 nm diode laser irradiation. These results point to the potential usage of F-CuS in treating human cancer.

Keywords: apoptosis; chemotherapy; copper sulfide nanoparticles; fucodian; photothermal therapy.