Crystal structure of DlyL, a mannose-specific lectin from Dioclea lasiophylla Mart. Ex Benth seeds that display cytotoxic effects against C6 glioma cells

Int J Biol Macromol. 2018 Jul 15:114:64-76. doi: 10.1016/j.ijbiomac.2018.03.080. Epub 2018 Mar 17.
No abstract available

Keywords: Crystal structure; DlyL; Glioma.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Binding Sites
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Survival / drug effects
  • Crystallization
  • Dioclea / chemistry*
  • Glioma
  • Mannose-Binding Lectins / chemistry*
  • Mannose-Binding Lectins / isolation & purification
  • Mannose-Binding Lectins / pharmacology
  • Molecular Docking Simulation
  • Plant Lectins / chemistry*
  • Plant Lectins / isolation & purification
  • Plant Lectins / pharmacology
  • Protein Binding
  • Protein Conformation
  • Rats
  • Seeds / chemistry*

Substances

  • Mannose-Binding Lectins
  • Plant Lectins