Advances in liquid biopsy approaches for early detection and monitoring of cancer

Genome Med. 2018 Mar 20;10(1):21. doi: 10.1186/s13073-018-0533-6.

Abstract

Progress in sensitive analytical approaches has opened new avenues for the detection of cells or products such as circulating cell-free DNA released by tumors. These 'liquid biopsies' are being explored in clinical trials for early cancer detection, prediction of recurrent disease, and assessment of therapeutic resistance mechanisms.

Keywords: Biomarker; Circulating tumor cells; Early detection; Liquid biopsy; Minimal residual disease; ctDNA.

MeSH terms

  • Early Detection of Cancer*
  • Humans
  • Liquid Biopsy / methods*
  • Neoplasm Staging
  • Neoplasm, Residual / pathology
  • Neoplasms / diagnosis*
  • Precision Medicine