mcr-1 in Carbapenemase-Producing Klebsiella pneumoniae with Hospitalized Patients, Portugal, 2016-2017

Emerg Infect Dis. 2018 Apr;24(4):762-766. doi: 10.3201/eid2404.171787.

Abstract

We describe a hospital-based outbreak caused by multidrug-resistant, Klebsiella pneumoniae carbapenemase 3-producing, mcr-1-positive K. pneumoniae sequence type 45 in Portugal. mcr-1 was located in an IncX4 plasmid. Our data highlight the urgent need for systematic surveillance of mcr-1 to support adequate therapeutic choices in the nosocomial setting.

Keywords: IncX4; Klebsiella pneumoniae; Portugal; ST45; antimicrobial resistance; bacteria; carbapenem; colonization; mcr; mcr-1; multidrug resistance; nosocomial infection; outbreak; plasmid-mediated colistin resistance.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • History, 21st Century
  • Hospitalization*
  • Humans
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / history
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Multilocus Sequence Typing
  • Portugal / epidemiology
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • carbapenemase