MicroRNA-585 suppresses tumor proliferation and migration in gastric cancer by directly targeting MAPK1

Biochem Biophys Res Commun. 2018 Apr 30;499(1):52-58. doi: 10.1016/j.bbrc.2018.03.116. Epub 2018 Mar 19.

Abstract

Increasing evidence reveals that microRNA contributes to the development and progression of gastric cancer (GC), but the roles of miR-585 in GC remain unclear. In this study, we confirmed that miR-585 was down-regulated in GC tissues and cell lines and that miR-585 expression was related to extent of invasion, TNM stage, lymph node invasion and poor prognosis. Our results showed that miR-585 inhibits the proliferation and migration of GC, and MAPK1 is a direct and functional target of miR-585. Our study sheds light on the role of miR-585 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-585 may serve as a new potential marker for monitoring and treating GC.

Keywords: Gastric cancer; MAPK1; Migration; Proliferation; miR-585.

MeSH terms

  • Aged
  • Animals
  • Base Sequence
  • Binding Sites
  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lymphatic Metastasis
  • Male
  • Mice
  • Mice, Nude
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Middle Aged
  • Mitogen-Activated Protein Kinase 1 / genetics*
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Prognosis
  • Signal Transduction
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology
  • Survival Analysis

Substances

  • Biomarkers, Tumor
  • MIRN585 microRNA, human
  • MicroRNAs
  • MAPK1 protein, human
  • Mitogen-Activated Protein Kinase 1