Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

Verena Hiebl; Angela Ladurner; Simone Latkolik; Verena M Dirsch

doi:10.1016/j.biotechadv.2018.03.003

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

Biotechnol Adv. 2018 Nov 1;36(6):1657-1698. doi: 10.1016/j.biotechadv.2018.03.003. Epub 2018 Mar 13.

Authors

Verena Hiebl¹, Angela Ladurner², Simone Latkolik¹, Verena M Dirsch¹

Affiliations

¹ University of Vienna, Department of Pharmacognosy, Althanstrasse 14, 1090 Vienna, Austria.
² University of Vienna, Department of Pharmacognosy, Althanstrasse 14, 1090 Vienna, Austria. Electronic address: angela.ladurner@univie.ac.at.

PMID: 29548878
DOI: 10.1016/j.biotechadv.2018.03.003

Abstract

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets. This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.

Keywords: Farnesoid X receptor; Liver X receptor; Metabolic syndrome; Natural products; Nuclear receptors; Precision medicine; Retinoid X receptor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biological Products* / chemistry
Biological Products* / pharmacology
Cells, Cultured
Humans
Mice
Receptors, Cytoplasmic and Nuclear* / drug effects
Receptors, Cytoplasmic and Nuclear* / metabolism

Substances

Biological Products
Receptors, Cytoplasmic and Nuclear