Effect of multi-walled carbon nanotubes on the cross-linking density of the poly(glycerol sebacate) elastomeric nanocomposites

Yi Yan; Vitor Sencadas; Tiantian Jin; Xufeng Huang; Wilford Lie; Dongbin Wei; Zhengyi Jiang

doi:10.1016/j.jcis.2018.03.015

Effect of multi-walled carbon nanotubes on the cross-linking density of the poly(glycerol sebacate) elastomeric nanocomposites

J Colloid Interface Sci. 2018 Jul 1:521:24-32. doi: 10.1016/j.jcis.2018.03.015. Epub 2018 Mar 7.

Authors

Yi Yan¹, Vitor Sencadas², Tiantian Jin³, Xufeng Huang³, Wilford Lie⁴, Dongbin Wei¹, Zhengyi Jiang⁵

Affiliations

¹ School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia.
² School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia; ARC Center of Excellence for Electromaterials Science, University of Wollongong, 2522 NSW, Australia. Electronic address: victors@uow.edu.au.
³ Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
⁴ School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
⁵ School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: jiang@uow.edu.au.

PMID: 29547786
DOI: 10.1016/j.jcis.2018.03.015

Abstract

Processing conditions deeply affect the mechanical, chemical and biological properties of elastomeric based nanocomposites. In this work, multi-walled carbon nanotubes (MWCNTs) were dispersed in poly(glycerol sebacate) (PGS) prepolymer, followed by curing under vacuum at 120 °C. It was observed an increase of the water contact angle with the amount of MWCNTs added, as well as the tensile strength and Young modulus, without compromising the elastomeric behaviour of the pristine PGS matrix. The cross-linking degree was determined by the Flory-Rehner swelling method and through the mechanical rubber elasticity model, and an increase of more than six-fold was observed, which demonstrates the chemical conjugation between the MWCNTs and the PGS polymer chains, resulting in stiff and elastomeric nanocomposites. Finally, in vitro cell culture of adult mouse hypothalamus neurons A59 cells showed good support for cell viability and stimulation for axons and dendrites growth. The unique features of these nanocomposites make them promise for biomedical applications, as soft tissue substrates with tailored mechanical properties.

Keywords: Biocompatibility; Biomedical applications; Carbon nanotubes; Nanocomposites; Poly(glycerol sebacate).