A new family of sesterterpenoids isolated around the Pacific Rim

Nat Prod Rep. 2018 Mar 21;35(3):210-219. doi: 10.1039/C7NP00049A.

Abstract

Covering: 2009 up to the end of 2017 There has been a recent eruption in the number of known marine sesterterpenoids which have been isolated from Pacific Rim marine organisms. These compounds have novel and unusual structures that exhibit incredibly potent and varied bioactivities. This review details the isolation, biological testing and prospects for this exciting new family with discussion of their potential biogenetic origins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Aquatic Organisms / chemistry
  • Biological Products / chemistry
  • Biological Products / isolation & purification
  • Biological Products / pharmacology*
  • Cell Differentiation / drug effects
  • Cyclic AMP / metabolism
  • Drug Evaluation, Preclinical / methods
  • Humans
  • Molecular Structure
  • Pacific Ocean
  • Porifera / chemistry
  • Sesterterpenes / chemistry*
  • Sesterterpenes / isolation & purification*
  • Sesterterpenes / pharmacology
  • Stem Cells / drug effects

Substances

  • Anti-HIV Agents
  • Biological Products
  • Sesterterpenes
  • isophorbasone A
  • Cyclic AMP