Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings

Patricia E Molina; Liz Simon; Angela M Amedee; David A Welsh; Tekeda F Ferguson

doi:10.1093/alcalc/agy016

Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings

Alcohol Alcohol. 2018 Jul 1;53(4):439-447. doi: 10.1093/alcalc/agy016.

Authors

Patricia E Molina¹, Liz Simon¹, Angela M Amedee¹, David A Welsh¹, Tekeda F Ferguson¹

Affiliation

¹ Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol and Drug Abuse Center of Excellence, LSUHSC, 1901 Perdido St., New Orleans, LA, USA.

Abstract

: Effective combined antiretroviral therapy regimens have extended survival of persons living with HIV (PLWH). Heavy alcohol consumption is common in PLWH. This overview integrates evidence from clinical and preclinical research to identify salient alcohol-related mechanisms and comorbidities contributing to disease pathogenesis and accelerated aging and senescence in PLWH.

Publication types

Review

MeSH terms

Aging / drug effects*
Alcohol Drinking / adverse effects*
Alcohol Drinking / epidemiology*
Comorbidity
HIV Infections / epidemiology*
HIV Infections / pathology
HIV Infections / psychology*
Humans

Grants and funding

P60 AA009803/AA/NIAAA NIH HHS/United States