The role of ROS-induced autophagy in hepatocellular carcinoma

Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):306-312. doi: 10.1016/j.clinre.2018.01.005. Epub 2018 Mar 12.

Abstract

Hepatocellular carcinoma (HCC) is a main cause of cancer-related mortality and its etiology is not fully understood. As prominent factors that regulate cellular homeostasis, both reactive oxygen species (ROS) and autophagy are considered to play an essential role in the liver carcinogenesis. However, the crosstalk between ROS and autophagy is not well characterized in the pathogenesis of HCC. This review summarizes the roles of autophagy in ROS-mediated hepatocarcinogenesis and discusses the role of ROS-induced autophagy in HCC cell fate decision following treatment with chemotherapeutic agents in preclinical settings, which may allow the identification of novel strategies for the treatment of HCC.

Keywords: Autophagy; Chemotherapy; Hepatocellular carcinoma (HCC); Pathogenesis; Reactive oxygen species (ROS).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Apoptosis / physiology
  • Autophagy / drug effects
  • Autophagy / physiology*
  • Bevacizumab / therapeutic use
  • Carcinogenesis
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / physiopathology*
  • DNA Damage / physiology
  • Humans
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / physiopathology*
  • Oxaliplatin / therapeutic use
  • Oxidative Stress / physiology
  • Pyrans / therapeutic use
  • Reactive Oxygen Species / metabolism*

Substances

  • Antineoplastic Agents
  • Pyrans
  • Reactive Oxygen Species
  • Oxaliplatin
  • Bevacizumab
  • salinomycin