Abstract
microRNAs are promising biomarkers for diverse cardiovascular diseases. While quantification of the small non-coding RNAs is routinely performed in the research laboratory, clinical-grade assessment of microRNAs in central laboratory environments or point-of-care testing is still in its infancy. In this review, we provide an overview on microRNAs as biomarkers for acute coronary syndromes and highlight promising technical approaches for microRNA-based assays systems.
Keywords:
acute coronary syndromes (ACS); assay; microRNA; troponin.
MeSH terms
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Acute Coronary Syndrome / blood
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Acute Coronary Syndrome / diagnosis*
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Acute Coronary Syndrome / genetics*
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Acute Disease
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Biomarkers / blood
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Biomarkers / metabolism
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Cardiovascular Diseases / genetics
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Glycopeptides / blood
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Humans
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Immunoassay / methods
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MicroRNAs / blood
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MicroRNAs / genetics*
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Myocardial Infarction / blood
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Point-of-Care Testing / statistics & numerical data
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Predictive Value of Tests
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Prognosis
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Real-Time Polymerase Chain Reaction / methods
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ST Elevation Myocardial Infarction / blood
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ST Elevation Myocardial Infarction / genetics
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Troponin T / blood
Substances
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Biomarkers
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Glycopeptides
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MicroRNAs
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Troponin T
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copeptins