microRNA assays for acute coronary syndromes

Diagnosis (Berl). 2016 Dec 1;3(4):183-188. doi: 10.1515/dx-2016-0025.

Abstract

microRNAs are promising biomarkers for diverse cardiovascular diseases. While quantification of the small non-coding RNAs is routinely performed in the research laboratory, clinical-grade assessment of microRNAs in central laboratory environments or point-of-care testing is still in its infancy. In this review, we provide an overview on microRNAs as biomarkers for acute coronary syndromes and highlight promising technical approaches for microRNA-based assays systems.

Keywords: acute coronary syndromes (ACS); assay; microRNA; troponin.

Publication types

  • Review

MeSH terms

  • Acute Coronary Syndrome / blood
  • Acute Coronary Syndrome / diagnosis*
  • Acute Coronary Syndrome / genetics*
  • Acute Disease
  • Biomarkers / blood
  • Biomarkers / metabolism
  • Cardiovascular Diseases / genetics
  • Glycopeptides / blood
  • Humans
  • Immunoassay / methods
  • MicroRNAs / blood
  • MicroRNAs / genetics*
  • Myocardial Infarction / blood
  • Point-of-Care Testing / statistics & numerical data
  • Predictive Value of Tests
  • Prognosis
  • Real-Time Polymerase Chain Reaction / methods
  • ST Elevation Myocardial Infarction / blood
  • ST Elevation Myocardial Infarction / genetics
  • Troponin T / blood

Substances

  • Biomarkers
  • Glycopeptides
  • MicroRNAs
  • Troponin T
  • copeptins