Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Farid Talih; Nour Y Gebara; Farah S Andary; Stefania Mondello; Firas Kobeissy; Raffaele Ferri

doi:10.1016/j.smrv.2018.02.002

Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers

Sleep Med Rev. 2018 Oct:41:133-140. doi: 10.1016/j.smrv.2018.02.002. Epub 2018 Feb 13.

Authors

Farid Talih¹, Nour Y Gebara², Farah S Andary³, Stefania Mondello⁴, Firas Kobeissy³, Raffaele Ferri⁵

Affiliations

¹ Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: ft10@aub.edu.lb.
² Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: nyg00@mail.aub.edu.
³ Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
⁴ Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy.
⁵ Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy.

PMID: 29534856
DOI: 10.1016/j.smrv.2018.02.002

Abstract

Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.

Keywords: Biomarkers; Bipolar disorder; Circadian rhythm sleep-wake disorders; Delayed sleep wake phase disorder; Melatonin; Mood disorder; Sleep disorders.

Publication types

Review

MeSH terms

Biomarkers
Bipolar Disorder / complications*
Bipolar Disorder / physiopathology*
Humans
Sleep Disorders, Circadian Rhythm / etiology
Sleep Disorders, Circadian Rhythm / physiopathology*
Sleep Disorders, Circadian Rhythm / psychology

Substances

Biomarkers