Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

Rohitesh Kumar; Sandra Duffy; Vicky M Avery; Anthony R Carroll; Rohan A Davis

doi:10.1021/acs.jnatprod.7b00992

Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

J Nat Prod. 2018 Apr 27;81(4):1079-1083. doi: 10.1021/acs.jnatprod.7b00992. Epub 2018 Mar 13.

Authors

Rohitesh Kumar¹, Sandra Duffy¹, Vicky M Avery¹, Anthony R Carroll¹, Rohan A Davis¹

Affiliation

¹ Griffith Institute for Drug Discovery, Griffith University , Brisbane , QLD 4111 , Australia.

PMID: 29533611
DOI: 10.1021/acs.jnatprod.7b00992

Abstract

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline-serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC₅₀ of 7.7 μM. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Antimalarials / chemistry
Antimalarials / pharmacology
Australia
Biological Products / chemistry
Biological Products / pharmacology
Eremophila Plant / chemistry*
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Roots / chemistry*
Plasmodium falciparum / drug effects
Quinolines / chemistry*

Substances

Alkaloids
Antimalarials
Biological Products
Plant Extracts
Quinolines
quinoline