[Mechanism of macrophage polarization on spinal cord injury]

Zhongguo Gu Shang. 2018 Jan 25;31(1):88-92. doi: 10.3969/j.issn.1003-0034.2018.01.017.
[Article in Chinese]

Abstract

Spinal cord injury is a serious trauma of the spinal and nervous system, local tissue destruction and microcirculation disturbance can lead to a more serious spinal cord injury and extensive necrosis of neurons. Spinal cord injury often accompany with Inflammation reaction producing a variety of cytokines and bioactive substances, result in macrophage polarization. M1 macrophages polarization are induced by IFN-γ, LPS, TNF-α and so on, it show the damage and proinflammatory effect. M2 macrophages polarization are caused by IL-4, IL-10, IL-13 and show the recovery and anti-inflammatory effect. However, clinical treatment after spinal cord injury is very limited, inhibition of proinflammatory and promotion of anti-inflammatory by regulating the M1 macrophages and M2 macrophages is a new direction for the treatment of spinal cord injury. The article will review different phenotype and function of macrophages after spinal cord injury.

Keywords: Macrophage; Review literature; Spinal cord injury.

Publication types

  • Review

MeSH terms

  • Cytokines / immunology*
  • Humans
  • Inflammation / immunology*
  • Macrophages / cytology*
  • Macrophages / immunology
  • Spinal Cord Injuries / immunology*

Substances

  • Cytokines