Prevalence of Myositis-Specific Antibodies in Idiopathic Interstitial Pneumonias

Laurens J De Sadeleer; Ellen De Langhe; Nicolas Bodart; Alain Vigneron; Xavier Bossuyt; Wim A Wuyts

doi:10.1007/s00408-018-0108-8

Prevalence of Myositis-Specific Antibodies in Idiopathic Interstitial Pneumonias

Lung. 2018 Jun;196(3):329-333. doi: 10.1007/s00408-018-0108-8. Epub 2018 Mar 12.

Authors

Laurens J De Sadeleer^{1

2}, Ellen De Langhe^{3

4}, Nicolas Bodart⁵, Alain Vigneron⁵, Xavier Bossuyt^{6

7}, Wim A Wuyts^{8

9}

Affiliations

¹ Department of Pneumology, University Hospitals Leuven (UZ Leuven), Herestraat 49, 3000, Louvain, Belgium. laurens.desadeleer@kuleuven.be.
² Laboratory of Pneumology, Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, Louvain, Belgium. laurens.desadeleer@kuleuven.be.
³ Department of Rheumatology, University Hospitals Leuven (UZ Leuven), Louvain, Belgium.
⁴ Laboratory Tissue Homeostasis and Disease, Department Development and Regeneration, KU Leuven, Louvain, Belgium.
⁵ D-Tek S.A., Mons, Belgium.
⁶ Department of Laboratory Medicine, Immunology, University Hospitals Leuven (UZ Leuven), Louvain, Belgium.
⁷ Experimental Laboratory Immunology, Department of Microbiology and Immunology, KU Leuven, Louvain, Belgium.
⁸ Department of Pneumology, University Hospitals Leuven (UZ Leuven), Herestraat 49, 3000, Louvain, Belgium.
⁹ Laboratory of Pneumology, Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), KU Leuven, Louvain, Belgium.

PMID: 29532165
DOI: 10.1007/s00408-018-0108-8

Abstract

Although included in the serological domain of the 'interstitial pneumonia with auto-immune features' (IPAF) research statement, the search for myositis-specific antibodies (MSA) is not incorporated in routine clinical practice. The objective of the study was to evaluate MSA prevalence in an idiopathic interstitial pneumonia (IIP) cohort (n = 68) with suggestive morphological interstitial lung disease patterns. Twelve of 68 patients (17.6%) carried MSA, whereof only two were anti-nuclear antibody-positive. Besides female gender, no demographic or pulmonary function parameter was predictive for MSA positivity. MSA were present in 32.4% of IPAF patients (n = 37), being essential for IPAF diagnosis in four of them (10.8%).

Keywords: Connective tissue disease-related lung disease; Interstitial lung diseases; Interstitial pneumonia with auto-immune features; Myositis-specific antibodies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphatases / immunology
Aged
Amino Acyl-tRNA Synthetases / immunology
Anti-Citrullinated Protein Antibodies / immunology
Antibodies, Antinuclear / immunology
Autoantibodies / immunology*
DNA-Binding Proteins / immunology
Female
Humans
Hydroxymethylglutaryl CoA Reductases / immunology
Idiopathic Interstitial Pneumonias / immunology*
Interferon-Induced Helicase, IFIH1 / immunology
Male
Middle Aged
Retrospective Studies
Rheumatoid Factor / immunology
Sex Factors
Transcription Factors / immunology
Ubiquitin-Activating Enzymes / immunology

Substances

Anti-Citrullinated Protein Antibodies
Antibodies, Antinuclear
Autoantibodies
DNA-Binding Proteins
Jo-1 antibody
Mi-2 antibodies
SS-A antibodies
TRIM33 protein, human
Transcription Factors
UBA2 protein, human
Rheumatoid Factor
HMGCR protein, human
Hydroxymethylglutaryl CoA Reductases
Adenosine Triphosphatases
IFIH1 protein, human
MORC3 protein, human
Interferon-Induced Helicase, IFIH1
Amino Acyl-tRNA Synthetases
SAE1 protein, human
Ubiquitin-Activating Enzymes