Successful Treatment of Intestinal Mycosis Caused by a Simultaneous Infection with Lichtheimia ramosa and Aspergillus calidoustus

Intern Med. 2018 Aug 15;57(16):2421-2424. doi: 10.2169/internalmedicine.0254-17. Epub 2018 Mar 9.

Abstract

A 53-year-old woman was hospitalized due to septic shock after developing pneumococcal pneumonia after undergoing esophageal cancer surgery. Her transverse colon became perforated after receiving antimicrobial chemotherapy; therefore, emergency subtotal colectomy was performed. Fungi detected in both her colon tissue and a drainage sample indicated intestinal mucormycosis. Early intensive treatment with high-dose liposomal amphotericin B was successful, and she was subsequently discharged from the hospital. The fungal isolates were identified to be Lichtheimia ramosa and Aspergillus calidoustus via gene sequencing using panfungal primers as well as species-specific primers against elongation factor 1 and beta-tubulin for detecting Lichtheimia and Aspergillus, respectively.

Keywords: Aspergillus calidoustus; Lichtheimia ramosa; fungal infection; intestinal mucormycosis; zygomycosis.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Aspergillus / isolation & purification*
  • Female
  • Humans
  • Intestinal Diseases / diagnosis
  • Intestinal Diseases / drug therapy*
  • Intestinal Diseases / microbiology*
  • Middle Aged
  • Mucormycosis / diagnosis*
  • Mucormycosis / drug therapy*
  • Treatment Outcome

Substances

  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B