Soft tissue sarcoma accounts for almost 7% of all malignant tumours in children and adolescents. This heterogeneous group of mesenchymal and neuroectodermal tissue neoplasms can be characterized by common biological and clinics traits. Bioactive lipids are described as lipids, the levels of which – when changed – lead to changes in cell functioning. The role of bioactive lipids in the biology of neoplasmatic cells is unquestionable. In this paper we present an overview of articles describing the impact of selected bioactive lipids on the development of sarcoma in children.