Graphene Oxide as Scaffolds for Stem Cells: An Overview

M Duran; A C M Luzo; J G de Souza; W J Favaro; P Garcia; N Duran

doi:10.2174/1566524018666180308111915

Graphene Oxide as Scaffolds for Stem Cells: An Overview

Curr Mol Med. 2017;17(9):619-626. doi: 10.2174/1566524018666180308111915.

Authors

M Duran^{1

2}, A C M Luzo³, J G de Souza¹, W J Favaro^{1

2}, P Garcia^{1

2}, N Duran^{2

4

5}

Affiliations

¹ Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, Brazil.
² NanoBioss-Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.
³ Molecular Biology Laboratory, Hematology Hemotherapy Centre, Faculty of Medical Science, University of Campinas, Campinas, SP, Brazil.
⁴ Institute of Chemistry, Biological Chemistry Laboratory, University of Campinas, Campinas, SP, Brazil.
⁵ Nanomedicine Research Unit (NANOMED), Universidade Federal do ABC, Santo André, SP, Brazil.

PMID: 29521226
DOI: 10.2174/1566524018666180308111915

Abstract

Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis, oligodendrogenesis, adipogenic and epithelial differentiation is also discussed. Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs differentiation and proliferation are final topics that are being discussed.

Keywords: Stem cells; adipose tissue derived mesenchymal stromal/stem cells; differentiation; graphene oxide; tissue engineering; topography..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adipose Tissue / cytology*
Animals
Cell Differentiation*
Cells, Cultured
Graphite / chemistry*
Humans
Mesenchymal Stem Cells / cytology*
Osteogenesis*
Tissue Engineering / methods*
Tissue Scaffolds

Substances

Graphite