Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR

Juan A Aguilar; Raquel Belda; Benjamin R Gaunt; Alan M Kenwright; Ilya Kuprov

doi:10.1002/mrc.4727

Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR

Magn Reson Chem. 2018 Oct;56(10):969-975. doi: 10.1002/mrc.4727. Epub 2018 Apr 11.

Authors

Juan A Aguilar¹, Raquel Belda¹, Benjamin R Gaunt¹, Alan M Kenwright¹, Ilya Kuprov²

Affiliations

¹ Department of Chemistry, University of Durham, Durham, UK.
² Department of Chemistry, University of Southampton, Southampton, UK.

PMID: 29520830
DOI: 10.1002/mrc.4727

Abstract

Recent developments in data sampling and processing techniques have made it possible to acquire 2-dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of 2-dimensional techniques including TOCSY and HSQC. In this paper, we investigate some of the problems in applying such techniques to COSY spectra and suggest a modification to the classic experiment that alleviates some of these problems.