One-Step Preparation of Phenyl Boron-Modified Magnetic Mesoporous Silica for Selective Enrichment of cis-Diol-Containing Substances

Hua Fu; Jing Hu; Min Zhang; Yuerong Wang; Hongyang Zhang; Ping Hu

doi:10.3390/molecules23030603

One-Step Preparation of Phenyl Boron-Modified Magnetic Mesoporous Silica for Selective Enrichment of cis-Diol-Containing Substances

Molecules. 2018 Mar 7;23(3):603. doi: 10.3390/molecules23030603.

Authors

Hua Fu^{1

2}, Jing Hu³, Min Zhang⁴, Yuerong Wang⁵, Hongyang Zhang⁶, Ping Hu⁷

Affiliations

¹ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. fuhua8711@126.com.
² School of Chemical Engineering, Qinghai University, Xining 810016, China. fuhua8711@126.com.
³ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. hjhuali2012@163.com.
⁴ Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. zhangm@ecust.edu.cn.
⁵ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. wangyuerong@ecust.edu.cn.
⁶ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. hongyang_zhang@ecust.edu.cn.
⁷ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. huping@ecust.edu.cn.

Abstract

For enrichment and separation of cis-diol-containing compounds from biomatrix, a new type of magnetic nanoparticles named MS-48-PBSC, whichwas facilely prepared in a one-step heterogeneous reaction. The morphology results demonstrated that the MS-48-PBSC was a spherical nanomaterial containing a core of silica-coated magnetic particle with a diameter of about 200 nm, and a cover layer of mesoporous silica with a thickness of approximate 50 nm. The characterization results showed that MS-48-PBSC presented a pore size of 4.2 nm, a surface area of 548 m²·g^-1, and a pore volume of 0.30 cm³·g^-1. The MS-48-PBSC also exhibited magnetism of 42 emu·g^-1 that contributed to the easy separation of magnetic nanomaterial within 30 s from the matrix with the aid of the external magnetic field. In addition, the MS-48-PBSC exhibited high adsorption capacity for adenosine, xanthosine, uridine, sialic acid, and teicoplanin with 0.60, 0.51, 0.42, 0.75, and 1.26 mg/g, respectively, and showed a high selectivity for the cis-diol structure compounds, relative to interferences of bovine serum albumin, guanine, uric acid, and xanthine. The recoveries of adenosine, xanthosine, uridine, sialic acid, and teicoplanin were 71.8-114.1% with relative standard deviation (RSD) ≤ 8.6%, and the enrichment factors of them were 8-11. MS-48-PBSC exhibited quick separation capability from matrix, high adsorption capacity and size exclusion for bovine serum albumin, which could meet the requirements of separation and enrichment for substances with a cis-diol structure.

Keywords: cis-diol-containing substance; magnetic solid-phase extraction; one-step preparation; phenylboronic acid; selective enrichment.

MeSH terms

Adsorption
Boron / chemistry*
Hydrogen-Ion Concentration
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / ultrastructure
Porosity
Silicon Dioxide / chemistry*
Solid Phase Extraction
Spectroscopy, Fourier Transform Infrared
Temperature
X-Ray Diffraction

Substances

Magnetite Nanoparticles
Silicon Dioxide
Boron