As a programmed cell death manner which is distinguished from apoptosis and autophagy, necroptosis is a newly discovered pathway of regulated necrosis that requires the protein receptor interacting protein kinases 1 and 3 and mixed lineage kinase domain-like protein. Necroptosis is mediated by death receptors, toll-like receptors and probably other mediators. Emerging evidences have delineated that necroptosis plays an important role in the occurrence and development of various blinding eye diseases. In this review, the related mechanism of necroptosis, the relationship between necroptosis and multiple blinding eye diseases, such as age-related macular degeneration, retinitis pigmentosa and glaucoma, and the potential therapeutic targets of necroptosis are discussed. (Chin J Ophthalmol, 2018, 54: 234-240).
程序性坏死是一种新近发现的区别于凋亡和自噬的细胞程序性死亡方式，由受体相互作用蛋白激酶（RIPK）1、RIPK3和混合系激酶区域样蛋白介导。程序性坏死可由死亡受体和Toll样受体等激活而引发。近年研究发现程序性坏死在多种致盲性眼病的发生和发展中扮演重要角色。通过探讨程序性坏死的相关分子机制，就程序性坏死与多种致盲性眼病，如年龄相关性黄斑变性、视网膜色素变性和青光眼的关系以及程序性坏死的潜在治疗靶点进行综述，以期为相关研究提供参考。（中华眼科杂志，2018，54：234-240）.
Keywords: Apoptosis; Glaucoma; Macular degeneration; Receptor-interacting protein serine-threonine kinases; Retinitis pigmentosa.