New Bioactive Metabolites from the Marine-derived Fungi Aspergillus

Mini Rev Med Chem. 2018;18(13):1072-1094. doi: 10.2174/1389557518666180305160856.

Abstract

Recently, the marine-derived Aspergillus present as producers of a large number of structurally novel secondary metabolites. Some of these metabolites have shown antitumor, antimicrobial, anti-inflammatory, antioxidant and enzymatic activities, and may be promising resources for new therapeutic drugs. This review sums up 232 new bioactive metabolites from the marine-derived Aspergillus with classification through their biological activities and chemical structures in 2006-2016. Besides, structure-activity relationships of some compounds are explored.

Keywords: Marine-derived Aspergillus; antimicrobial; antioxidant; cytotoxic; enzymatic activities; metabolites; structureactivity..

Publication types

  • Review

MeSH terms

  • Acetylcholinesterase / chemistry
  • Acetylcholinesterase / metabolism
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • Aspergillus / chemistry*
  • Aspergillus / metabolism
  • Cell Survival / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Seawater / microbiology
  • Terpenes / chemistry*
  • Terpenes / isolation & purification

Substances

  • Anti-Infective Agents
  • Antioxidants
  • Terpenes
  • Acetylcholinesterase