Polar Constituents of Salvia willeana (Holmboe) Hedge, Growing Wild in Cyprus

Theofilos Mailis; Helen Skaltsa

doi:10.3390/plants7010018

Polar Constituents of Salvia willeana (Holmboe) Hedge, Growing Wild in Cyprus

Plants (Basel). 2018 Mar 6;7(1):18. doi: 10.3390/plants7010018.

Authors

Theofilos Mailis¹, Helen Skaltsa¹

Affiliation

¹ Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 157 71 Athens, Greece. skaltsa@pharm.uoa.gr.

Abstract

Twenty compounds were isolated from the aerial parts of Salvia willeana (Holmboe) Hedge, growing wild in Cyprus. These compounds comprise one new and one known acetophenone, one megastigmane glucoside, five phenolic derivatives, two caffeic acid oligomers, three flavonoids, two lignans, two triterpene acids, one monoterpene glucoside, and two fatty acids. The structures of the isolated compounds were established by means of NMR [(Rotating-frame OverhauserEffect SpectroscopY) (¹H-¹H-COSY (COrrelation SpectroscopΥ), ¹H-¹³C-HSQC (Heteronuclear Single Quantum Correlation), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Effect SpectroscopY), ROESY (Rotating-frame Overhauser Effect SpectroscopY)] and MS spectral analyses. This is the first report of the natural occurrence of 4-hydroxy-acetophenone 4-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-d-glucopyranoside. A chemical review on the non-volatile secondary metabolites has been carried out. Based on the literature data, the analysis revealed that the chemical profile of S. willeana is close to that of S. officinalis L.

Keywords: ">d-glucopyranoside; 2D NMR; 4-hydroxy-acetophenone 4-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-; Salvia L: chemical review; Salvia willeana; megastigmane glucoside; phenolics; terpenes.