DNA methylation as a genomic marker of exposure to chemical and environmental agents

Richard R Meehan; John P Thomson; Antonio Lentini; Colm E Nestor; Sari Pennings

doi:10.1016/j.cbpa.2018.02.006

DNA methylation as a genomic marker of exposure to chemical and environmental agents

Curr Opin Chem Biol. 2018 Aug:45:48-56. doi: 10.1016/j.cbpa.2018.02.006. Epub 2018 Mar 2.

Authors

Richard R Meehan¹, John P Thomson², Antonio Lentini³, Colm E Nestor⁴, Sari Pennings⁵

Affiliations

¹ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: richard.meehan@igmm.ed.ac.uk.
² MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
³ Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 58183, Sweden.
⁴ Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 58183, Sweden. Electronic address: colm.nestor@liu.se.
⁵ Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, EH16 4TJ, UK. Electronic address: sari.pennings@ed.ac.uk.

PMID: 29505975
DOI: 10.1016/j.cbpa.2018.02.006

Abstract

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Methylation / drug effects*
Environmental Exposure / adverse effects*
Environmental Exposure / analysis
Environmental Pollutants / adverse effects*
Environmental Pollutants / toxicity
Epigenesis, Genetic / drug effects*
Epigenomics / methods
Humans

Substances

Environmental Pollutants

Abstract

Publication types

MeSH terms

Substances

Grants and funding