Advances in glycosylation-mediated cancer-targeted drug delivery

Lulu Cai; Zhipeng Gu; Jian Zhong; Di Wen; Guojun Chen; Lin He; Jun Wu; Zhen Gu

doi:10.1016/j.drudis.2018.02.009

Advances in glycosylation-mediated cancer-targeted drug delivery

Drug Discov Today. 2018 May;23(5):1126-1138. doi: 10.1016/j.drudis.2018.02.009. Epub 2018 Feb 28.

Authors

Lulu Cai¹, Zhipeng Gu², Jian Zhong³, Di Wen⁴, Guojun Chen⁴, Lin He⁵, Jun Wu⁶, Zhen Gu⁷

Affiliations

¹ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: lcai6@ncsu.edu.
² Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China.
³ School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁴ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
⁵ Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan 637000, China.
⁶ Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Engineering, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: wujun29@mail.sysu.edu.cn.
⁷ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. Electronic address: zgu@email.unc.edu.

PMID: 29501708
DOI: 10.1016/j.drudis.2018.02.009

Abstract

Targeted drug delivery for cancer therapy is expected to enhance therapeutic efficacy with minimized side effects, where the ligand-receptor recognition serves as a common targeting approach. Various ligands have been reported and carbohydrates, one of the crucial structures of tumor cell membranes, have been demonstrated effective for cell-selective binding. Hence, glycosylation-mediated cancer-targeted drug nanocarriers have received increasing attention in recent years. This review surveys a variety of glycosylated drug delivery systems as well as their applications for cancer therapy. Their challenges, opportunities, and future perspectives are also discussed in the end.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Delivery Systems*
Glycosylation
Humans
Neoplasms / drug therapy*