Emerging In Vitro 3D Tumour Models in Nanoparticle-Based Gene and Drug Therapy

Joanna K Wong; Amelia Seifalian; Rashin Mohseni; Amir Ali Hamidieh; Robert E MacLaren; Nagy Habib; Alexander M Seifalian

doi:10.1016/j.tibtech.2018.02.002

Emerging In Vitro 3D Tumour Models in Nanoparticle-Based Gene and Drug Therapy

Trends Biotechnol. 2018 May;36(5):477-480. doi: 10.1016/j.tibtech.2018.02.002. Epub 2018 Feb 27.

Authors

Joanna K Wong¹, Amelia Seifalian², Rashin Mohseni³, Amir Ali Hamidieh³, Robert E MacLaren⁴, Nagy Habib⁵, Alexander M Seifalian⁶

Affiliations

¹ School of Medicine, Imperial College London, London, UK.
² School of Medicine, University College London, London, UK.
³ Hematology-Oncology and Stem Cell Transplantation Centre, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁵ Faculty of Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.
⁶ Nanotechnology and Regenerative Medicine Centre (Ltd), The London BioScience Innovation Centre, London, UK. Electronic address: a.seifalian@gmail.com.

PMID: 29500003
DOI: 10.1016/j.tibtech.2018.02.002

Abstract

3D models are emerging as valuable tools for personalised nanoparticle-based cancer treatments. 3D models represent in vivo cancers more realistically than 2D patterns that are grown in Petri dishes. However, creating a 3D cancer model that mimics the complexity and heterogeneity of cancers in vivo remains difficult.

Keywords: 3D cancer model; drug delivery; gene therapy; nanoparticle.

Publication types

Letter
Comment

MeSH terms

Genetic Therapy
Humans
Nanoparticles*
Neoplasms*