Novel t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) chromosomal translocations in ischemic fasciitis: expanding the spectrum of pseudosarcomatous lesions with clonal pathogenetic link

Diagn Pathol. 2018 Mar 2;13(1):18. doi: 10.1186/s13000-018-0695-y.

Abstract

Background: Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be related to ischemic vascular events.

Case presentation: Herein, we report for the first time, two cytogenetic translocations, t(1;2)(p36.1;q23) and t(7;19)(q32;q13.3) in a 75 year-old ambulating female with a history of left total hip arthroplasty 20 years ago.

Conclusion: These translocations suggest a possible clonal pathogenetic link though their significance remains to be established.

Keywords: Clonal chromosomal translocations; Ischemic fasciitis; Pseudosarcoma.

MeSH terms

  • Aged
  • Chromosomes, Human*
  • Fasciitis / diagnosis
  • Fasciitis / genetics
  • Fasciitis / pathology*
  • Female
  • Humans
  • Ischemia / genetics
  • Piriformis Muscle Syndrome / diagnosis
  • Piriformis Muscle Syndrome / genetics*
  • Piriformis Muscle Syndrome / pathology*
  • Sciatica / diagnosis
  • Sciatica / genetics*
  • Sciatica / pathology*
  • Translocation, Genetic / genetics*

Supplementary concepts

  • Hip socket neuropathy