Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells

Miriama Kruta; Robert A J Signer

doi:10.1016/j.stem.2018.02.008

Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells

Cell Stem Cell. 2018 Mar 1;22(3):281-282. doi: 10.1016/j.stem.2018.02.008.

Authors

Miriama Kruta¹, Robert A J Signer²

Affiliations

¹ Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
² Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: rsigner@ucsd.edu.

PMID: 29499142
DOI: 10.1016/j.stem.2018.02.008

Abstract

The rapid proliferation and unlimited self-renewal of embryonic stem cells depends upon a permissive chromatin landscape that enables hypertranscription. In this issue of Cell Stem Cell, Bulut-Karslioglu et al. report that euchromatin and transcriptional output are enhanced by protein synthesis in embryonic stem cells (Bulut-Karslioglu et al., 2018).

Publication types

Comment

MeSH terms

Chromatin*
Embryonic Stem Cells*
Protein Biosynthesis

Substances

Chromatin