Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium

Tiffeny T Smith; Pranita D Tamma; Tiffany B Do; Kathryn E Dzintars; Yuan Zhao; Sara E Cosgrove; Edina Avdic

doi:10.1016/j.diagmicrobio.2018.01.027

Prolonged linezolid use is associated with the development of linezolid-resistant Enterococcus faecium

Diagn Microbiol Infect Dis. 2018 Jun;91(2):161-163. doi: 10.1016/j.diagmicrobio.2018.01.027. Epub 2018 Feb 3.

Authors

Tiffeny T Smith¹, Pranita D Tamma², Tiffany B Do³, Kathryn E Dzintars⁴, Yuan Zhao⁵, Sara E Cosgrove⁶, Edina Avdic⁴

Affiliations

¹ Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD, USA. Electronic address: tiffeny.smith@UTSouthwestern.edu.
² Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³ University of Maryland School of Pharmacy, Baltimore, MD, USA.
⁴ Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD, USA.
⁵ Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD, USA.
⁶ Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

PMID: 29496381
DOI: 10.1016/j.diagmicrobio.2018.01.027

Abstract

We assessed risk factors for and outcomes of linezolid-resistant vancomycin-resistant Enterococcus faecium (LRVREF) bacteremia over 7 years. Thirty-four LRVREF cases were matched to 68 linezolid-susceptible VREF controls. The odds of bacteremia with LRVREF increased by 7% for each additional day of prior linezolid exposure.

Keywords: Enterococcus faecium; Linezolid-resistant enterococci; VRE.

MeSH terms

Adult
Aged
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Multiple, Bacterial / drug effects*
Enterococcus faecium / drug effects*
Female
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / microbiology*
Humans
Linezolid / pharmacology*
Linezolid / therapeutic use
Male
Middle Aged
Retrospective Studies
Time Factors
Vancomycin-Resistant Enterococci / drug effects*

Substances

Anti-Bacterial Agents
Linezolid